Hepatitis B virus, hepatitis A virus and persistently elevated aminotransferases in hemophiliacs.
Publication/Presentation Date
1-1-1980
Abstract
To determine the exposure to hepatitis A and hepatitis B viruses (HAV, HBV) following intravenous replacement therapy in patients with classic hemophilia and to assess the role of these viruses in persistently elevated aminotransferases, sera were studied from 136 patients from 9 months to 67 years of age were transfused with either single-donor cryoprecipitate (CRYO) or Antihemophilic Factor Concentrate (AHF) for periods ranging from a few months to 15 years. Serologic evidence of past or present infection with HBV was detected in 90% of all 136 patients and in 85% of those 34 patients 10 years of age or younger. Sixty-four percent of those with serologic markers of hepatitis B had high titers of antibody to the hepatitis B surface antigen and low titers of antibody to the hepatitis B core antigen. These findings are consistent with the known high frequency of early exposure to HBV in hemophiliacs receiving replacement therapy and with recovery from these hepatitis B infections. Sixteen percent of these patients had persistently elevated aminotransferase levels; HBV could not be implicated as the cause of the enzyme elevations in most of these cases.
Volume
6
Issue
2
First Page
111
Last Page
118
ISSN
0146-6615
Published In/Presented At
Gerety, R. J., Eyster, M. E., Tabor, E., Drucker, J. A., Lusch, C. J., Prager, D., Rice, S. A., & Bowman, H. S. (1980). Hepatitis B virus, hepatitis A virus and persistently elevated aminotransferases in hemophiliacs. Journal of medical virology, 6(2), 111–118. https://doi.org/10.1002/jmv.1890060203
Disciplines
Medicine and Health Sciences
PubMedID
6264019
Department(s)
Department of Medicine
Document Type
Article