von Willebrand syndromes and mitral-valve prolapse; linked mesenchymal dysplasias.
Publication/Presentation Date
7-16-1981
Abstract
We searched for mitral-valve prolapse by two-dimensional echocardiography in 15 patients with von Willebrand syndromes to test the hypothesis that this bleeding disorder is actually a mesenchymal dysplasia that resembles the heritable disorders of connective tissue. This valvular abnormality was found in nine (60 per cent) of these patients, as compared with four (13.3 per cent) of 30 sex-matched and age-matched healthy controls. This difference was statistically significant (P less than 0.01). The association between these two disorders encourages a search for mitral-valve prolapse in persons with a von Willebrand syndrome. The complex of a von Willebrand syndrome and mitral-valve prolapse may be an example of a newly recognized category of related coagulation and cardiovascular disorders.
Volume
305
Issue
3
First Page
131
Last Page
134
ISSN
0028-4793
Published In/Presented At
Pickering, N. J., Brody, J. I., & Barrett, M. J. (1981). von Willebrand syndromes and mitral-valve prolapse; linked mesenchymal dysplasias. The New England journal of medicine, 305(3), 131–134. https://doi.org/10.1056/NEJM198107163050303
Disciplines
Medicine and Health Sciences
PubMedID
6787425
Department(s)
Department of Medicine
Document Type
Article