β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling
Publication/Presentation Date
7-11-2017
Abstract
BACKGROUND: Although β-blockers increase survival in patients with heart failure (HF), the mechanisms behind this protection are not fully understood, and not all patients with HF respond favorably to them. We recently showed that, in cardiomyocytes, a reciprocal down-regulation occurs between β
OBJECTIVES: The authors hypothesized that, in addition to salutary actions due to direct β
METHODS: We tested the in vitro effects of Meto in HEK293 cells and in ventricular cardiomyocytes isolated from neonatal rats. In vivo, we assessed the effects of Meto in MI wild-type and β
RESULTS: Here we report that, in vitro, Meto prevents catecholamine-induced down-regulation of S1PR
CONCLUSIONS: Our study uncovers a previously unrecognized mechanism by which β
Volume
70
Issue
2
First Page
182
Last Page
192
ISSN
1558-3597
Published In/Presented At
Cannavo, A., Rengo, G., Liccardo, D., Pun, A., Gao, E., George, A. J., Gambino, G., Rapacciuolo, A., Leosco, D., Ibanez, B., Ferrara, N., Paolocci, N., & Koch, W. J. (2017). β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling. Journal of the American College of Cardiology, 70(2), 182–192. https://doi.org/10.1016/j.jacc.2017.05.020
Disciplines
Medicine and Health Sciences
PubMedID
28683966
Department(s)
Department of Medicine, Department of Medicine Fellows and Residents, Fellows and Residents
Document Type
Article