Pulmonary hypertension in sickle cell disease.
Publication/Presentation Date
11-1-2004
Abstract
BACKGROUND: Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication.
METHODS: Sixty patients (> or =18 years of age; mean [+/- SD] age, 37 +/- 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index-adjusted nomogram.
RESULTS: The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (> or =75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension.
CONCLUSION: We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure.
Volume
117
Issue
9
First Page
665
Last Page
669
ISSN
0002-9343
Published In/Presented At
Ataga, K. I., Sood, N., De Gent, G., Kelly, E., Henderson, A. G., Jones, S., Strayhorn, D., Lail, A., Lieff, S., & Orringer, E. P. (2004). Pulmonary hypertension in sickle cell disease. The American journal of medicine, 117(9), 665–669. https://doi.org/10.1016/j.amjmed.2004.03.034
Disciplines
Medicine and Health Sciences
PubMedID
15501204
Department(s)
Department of Medicine
Document Type
Article