Residual Volume and Total Lung Capacity to Assess Reversibility in Obstructive Lung Disease.
Publication/Presentation Date
11-1-2016
Abstract
BACKGROUND: Reversibility of obstructive lung disease is traditionally defined by changes in FEV
METHODS: Responsiveness of residual volume and total lung capacity to bronchodilators was assessed with a retrospective analysis of pulmonary function tests of 965 subjects with obstructive lung disease as defined by the lower limit of normal based on National Health and Nutritional Examination Survey III prediction equations.
RESULTS: A statistically significant number of subjects demonstrated response to bronchodilators in their residual volume independent of response defined by FEV
CONCLUSIONS: A significant number of subjects classified as being nonresponsive based on spirometry have reversible residual volumes. Subjects whose residual volumes improve in response to bronchodilators represent an important subgroup of those with obstructive lung disease. The identification of this subgroup better characterizes the heterogeneity of obstructive lung disease. The clinical importance of these findings is unclear but warrants further study.
Volume
61
Issue
11
First Page
1505
Last Page
1512
ISSN
1943-3654
Published In/Presented At
McCartney, C. T., Weis, M. N., Ruppel, G. L., & Nayak, R. P. (2016). Residual Volume and Total Lung Capacity to Assess Reversibility in Obstructive Lung Disease. Respiratory care, 61(11), 1505–1512. https://doi.org/10.4187/respcare.04323
Disciplines
Medicine and Health Sciences
PubMedID
27555617
Department(s)
Department of Medicine
Document Type
Article