Marfan Syndrome Presenting as Spontaneous Coronary Artery Dissection and Arteriopathy.
INTRODUCTION: Spontaneous coronary artery dissection (SCAD) is a term used to define a spontaneous separation of the coronary artery wall not related to underlying risk factors, such as trauma or underlying atherosclerotic disease. While SCAD has a range of different etiologies, with fibromuscular dysplasia being the most common, most cases of SCAD have no concomitant arteriopathy.
CASE REPORT: Here we describe a case of a patient who presented to our institution with SCAD and evidence of an asymptomatic arteriopathy involving extracranial segments of the carotid and vertebral arteries, later found to have a pathogenic variant in the FBN1 gene and ultimately diagnosed with Marfan syndrome. This has only been rarely described in the literature as an etiology for SCAD.
CONCLUSION: Although rare, it is important to consider underlying connective tissue disorders in patients presenting with spontaneous coronary artery dissection and arteriopathy without underlying cardiovascular risk factors.
Published In/Presented At
Blech, B., Dhamija, R., & Ingall, T. (2021). Marfan Syndrome Presenting as Spontaneous Coronary Artery Dissection and Arteriopathy. The neurologist, 27(1), 34–36. https://doi.org/10.1097/NRL.0000000000000358
Medicine and Health Sciences
Department of Medicine