Keynote review: epithelial and endothelial barriers in human disease.

Publication/Presentation Date

3-15-2005

Abstract

There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance, generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.

Volume

10

Issue

6

First Page

395

Last Page

408

ISSN

1359-6446

Disciplines

Medicine and Health Sciences

PubMedID

15808819

Department(s)

Department of Medicine

Document Type

Article

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