Keynote review: epithelial and endothelial barriers in human disease.
Publication/Presentation Date
3-15-2005
Abstract
There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance, generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.
Volume
10
Issue
6
First Page
395
Last Page
408
ISSN
1359-6446
Published In/Presented At
Mullin, J. M., Agostino, N., Rendon-Huerta, E., & Thornton, J. J. (2005). Keynote review: epithelial and endothelial barriers in human disease. Drug discovery today, 10(6), 395–408. https://doi.org/10.1016/S1359-6446(05)03379-9
Disciplines
Medicine and Health Sciences
PubMedID
15808819
Department(s)
Department of Medicine
Document Type
Article