Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan.
Publication/Presentation Date
1-1-2015
Abstract
Takotsubo syndrome (TS), also known as broken heart syndrome, is characterized by left ventricle apical ballooning with elevated cardiac biomarkers and electrocardiographic changes suggestive of an acute coronary syndrome (ie, ST-segment elevation, T wave inversions, and pathologic Q waves). We report a case of 54-year-old woman with medical history of mitral valve prolapse and migraines, who was admitted to the hospital for substernal chest pain and electrocardiogram demonstrated 1/2 mm ST-segment elevation in leads II, III, aVF, V5, and V6 and positive troponin I. Emergent coronary angiogram revealed normal coronary arteries with moderately reduced left ventricular ejection fraction with wall motion abnormalities consistent with TS. Detailed history obtained retrospectively revealed that the patient took zolmitriptan sparingly only when she had migraines. But before this event, she was taking zolmitriptan 2-3 times daily for several days because of a persistent migraine headache. She otherwise reported that she is quite active, rides horses, and does show jumping without any limitations in her physical activity. There was no evidence of any recent stress or status migrainosus. Extensive literature search revealed multiple cases of coronary artery vasospasm secondary to zolmitriptan, but none of the cases were associated with TS.
Volume
22
Issue
2
First Page
52
Last Page
56
ISSN
1536-3686
Published In/Presented At
Garg, J., Aronow, W. S., Devabhaktuni, S., & Ahmad, H. (2015). Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan. American journal of therapeutics, 22(2), e52–e56. https://doi.org/10.1097/01.mjt.0000433938.07244.05
Disciplines
Medicine and Health Sciences
PubMedID
24100257
Department(s)
Department of Medicine, Fellows and Residents
Document Type
Article