Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.
Publication/Presentation Date
4-1-2002
Abstract
Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions shared no patterns, and the absence of donor sequences, including from family members, supports the idea that most changes arose from nontemplated mutation. The tandem mutations as a group are distinguished by consistently fewer transition changes and an A bias. We suggest this is one of several pathways of hypermutation diversifying shark antigen-receptor genes--point mutations, tandem mutations, and mutations with a G-C preference--that coevolved with or preceded gene rearrangement.
Volume
16
Issue
4
First Page
571
Last Page
582
ISSN
1074-7613
Published In/Presented At
Lee, S. S., Tranchina, D., Ohta, Y., Flajnik, M. F., & Hsu, E. (2002). Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity, 16(4), 571–582. https://doi.org/10.1016/s1074-7613(02)00300-x
Disciplines
Medicine and Health Sciences
PubMedID
11970880
Department(s)
Department of Medicine
Document Type
Article