Acute profound thrombocytopenia without bleeding complications after abciximab administration.
Publication/Presentation Date
5-1-1999
Abstract
Abciximab (c7E3) is the Fab fragment of the chimeric monoclonal antibody directed against glycoprotein IIb/IIIa found on the surface of platelets. It is the first FDA-approved platelet receptor glycoprotein inhibitor. Severe thrombocytopenia (defined as platelet count < 50 x 109/L) on first administration is a rare complication, occurring in only 1.6% of patients in the EPIC (Evaluation of 7E3 for the Prevention of Ischemic Complications) study. Bleeding complications were the rule in these thrombocytopenic patients as reported by EPIC investigators, Kereiakes et al. and Berkowitz et al. Platelet transfusions are required to reverse the bleeding diathesis. Intravenous IgG has not reportedly been helpful in reversing thrombocytopenia, and experience with corticosteroids is not reported in the literature. We report a case of acute profound thrombocytopenia following abciximab administration treated with platelet transfusion augmented by intravenous corticosteroids, in whom there was no bleeding complication.
Volume
11
Issue
5
First Page
313
Last Page
315
ISSN
1042-3931
Published In/Presented At
Elmi, F., Oza, R., & Mascarenhas, D. A. (1999). Acute profound thrombocytopenia without bleeding complications after abciximab administration. The Journal of invasive cardiology, 11(5), 313–315.
Disciplines
Medicine and Health Sciences
PubMedID
10745539
Department(s)
Department of Medicine
Document Type
Article