Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin.
Publication/Presentation Date
4-1-2007
Abstract
A 91-year-old woman who had been taking methotrexate for approximately 5 years for rheumatoid arthritis developed papules and nodules on her face that enlarged during 6 months. A series of biopsy specimens demonstrated a lymphoplasmacytic infiltrate with increasingly atypical histopathologic features that resembled diffuse large B-cell lymphoma. Epstein-Barr virus was not identified. Withdrawal of methotrexate resulted in complete resolution of all lesions within 8 weeks. This case illustrates the rare occurrence of methotrexate-associated lymphoproliferative disorder with primary presentation in the skin and documents clinical and histopathologic progression from early changes to fully developed lesions.
Volume
56
Issue
4
First Page
686
Last Page
690
ISSN
1097-6787
Published In/Presented At
Clarke, L. E., Junkins-Hopkins, J., Seykora, J. T., Adler, D. J., & Elenitsas, R. (2007). Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin. Journal of the American Academy of Dermatology, 56(4), 686–690. https://doi.org/10.1016/j.jaad.2006.09.011
Disciplines
Medicine and Health Sciences
PubMedID
17141365
Department(s)
Department of Medicine
Document Type
Article