Long-term paclitaxel-eluting stent outcomes in elderly patients.
Publication/Presentation Date
6-1-2009
Abstract
BACKGROUND: Although drug-eluting stents have become a mainstay of percutaneous coronary intervention, information about drug-eluting stents outcomes in elderly patients is limited. Data from the paclitaxel-eluting stent (PES) trials and registries were pooled to assess PES benefits relative to advancing patient age, including comparison with bare-metal stents.
METHODS AND RESULTS: Data from 5 randomized trials (2271 patients with PES, 1397 patients with bare-metal stents) and from 2 postmarket registries (7492 patients with PES) were pooled separately. Each dataset was stratified into age groups:70 years. At baseline, patients aged >70 years in both datasets had significantly more adverse characteristics than younger patients. Through 5 years, trial data showed that patients aged >70 years had higher death rates, but comparable rates of myocardial infarction, stent thrombosis, and target lesion revascularization with younger patients. Compared with patients with bare-metal stents, patients with PES aged >70 years had comparable rates of death, myocardial infarction, and stent thrombosis but a significantly lower target lesion revascularization rate (22.2 versus 10.2, P70 years had significantly higher death rates, but lower myocardial infarction, stent thrombosis, and target lesion revascularization rates, compared with younger patients. Although the mortality rates of patients aged >70 years were higher than those of younger patients, they were comparable with those of age- and gender-matched norms in the general population.
CONCLUSIONS: This analysis of almost 10 000 patients demonstrated that percutaneous coronary intervention with PES is a safe and an effective treatment option that should not be withheld based on age.
Volume
2
Issue
3
First Page
178
Last Page
187
ISSN
1941-7632
Published In/Presented At
Forman, D. E., Cox, D. A., Ellis, S. G., Lasala, J. M., Ormiston, J. A., Stone, G. W., Turco, M. A., Wei, J. Y., Joshi, A. A., Dawkins, K. D., & Baim, D. S. (2009). Long-term paclitaxel-eluting stent outcomes in elderly patients. Circulation. Cardiovascular interventions, 2(3), 178–187. https://doi.org/10.1161/CIRCINTERVENTIONS.109.855221
Disciplines
Medicine and Health Sciences
PubMedID
20031714
Department(s)
Department of Medicine
Document Type
Article