Predictors of infarct size after primary coronary angioplasty in acute myocardial infarction from pooled analysis from four contemporary trials.
Publication/Presentation Date
11-1-2007
Abstract
Determinates of infarct size in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) have been incompletely characterized, in part because of the limited sample size of previous studies. Databases therefore were pooled from 4 contemporary trials of primary or rescue PCI (EMERALD, COOL-MI, AMIHOT, and ICE-IT), in which the primary end point was infarct size assessed using technetium-99m sestamibi single-photon emission computed tomographic imaging, measured at the same core laboratory. Of 1,355 patients, infarct size was determined using technetium-99m sestamibi imaging in 1,199 patients (88.5%), at a mean time of 23 +/- 15 days. Median infarct size of the study population was 10% (interquartile range 0% to 23%; mean 14.9 +/- 16.1%). Using multiple linear regression analysis of 18 variables, left anterior descending infarct artery, baseline Thrombolysis In Myocardial Infarction grade 0/1 flow, male gender, and prolonged door-to-balloon time were powerful independent predictors of infarct size (all p
Volume
100
Issue
9
First Page
1370
Last Page
1375
ISSN
0002-9149
Published In/Presented At
Stone, G. W., Dixon, S. R., Grines, C. L., Cox, D. A., Webb, J. G., Brodie, B. R., Griffin, J. J., Martin, J. L., Fahy, M., Mehran, R., Miller, T. D., Gibbons, R. J., & O'Neill, W. W. (2007). Predictors of infarct size after primary coronary angioplasty in acute myocardial infarction from pooled analysis from four contemporary trials. The American journal of cardiology, 100(9), 1370–1375. https://doi.org/10.1016/j.amjcard.2007.06.027
Disciplines
Medicine and Health Sciences
PubMedID
17950792
Department(s)
Department of Medicine
Document Type
Article