Relation between leucocyte count, myonecrosis, myocardial perfusion, and outcomes following primary angioplasty.
Publication/Presentation Date
4-15-2007
Abstract
We examined whether leukocytosis is a negative prognostic factor in patients who underwent primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), and, if so, determined whether it is associated with impaired myocardial perfusion. Previous studies have identified leukocytosis as a predictor of mortality in AMI. Whether this association holds in patients how have undergone primary PCI using contemporary pharmacotherapy and correlates with impaired myocardial perfusion is unknown. Clinical outcomes and reperfusion success, using Thrombolysis In Myocardial Infarction (TIMI) flow and myocardial blush grades, were examined according to tertiles of baseline leukocyte count in 1,268 patients who underwent primary PCI for AMI in the CADILLAC trial. Patients with higher leukocyte count were younger and more likely to be current smokers. Preprocedure TIMI grade 0 flow was more frequent in patients with higher leukocyte counts, but postprocedural TIMI grade 3 flow rates were equally high (>94%) in all 3 groups. Myocardial blush grade 2/3 was achieved at similar rates after PCI in patients with low, intermediate, and high baseline leukocyte counts (52.0% vs 51.5% vs 50.1%, p = 0.8). Higher baseline leukocyte counts were associated with greater myonecrosis (p
Volume
99
Issue
8
First Page
1067
Last Page
1071
ISSN
0002-9149
Published In/Presented At
Prasad, A., Stone, G. W., Stuckey, T. D., Costantini, C. O., Mehran, R., Garcia, E., Tcheng, J. E., Cox, D. A., Grines, C. L., Lansky, A. J., & Gersh, B. J. (2007). Relation between leucocyte count, myonecrosis, myocardial perfusion, and outcomes following primary angioplasty. The American journal of cardiology, 99(8), 1067–1071. https://doi.org/10.1016/j.amjcard.2006.11.063
Disciplines
Medicine and Health Sciences
PubMedID
17437729
Department(s)
Department of Medicine
Document Type
Article