Predictors of and outcomes of early thrombosis following balloon angioplasty versus primary stenting in acute myocardial infarction and usefulness of abciximab (the CADILLAC trial).
Publication/Presentation Date
10-15-2004
Abstract
We sought to identify the predictors and clinical outcomes of early thrombosis after primary angioplasty and stenting for acute myocardial infarction (AMI). Little is known about the correlates and prognosis of acute and subacute thromboses after percutaneous coronary intervention (PCI) for AMI. We therefore studied the frequency, clinical determinants, and implications of early thrombosis in a large trial of patients who had primary PCI. In the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications trial, 2,082 patients who had AMI were randomized in a 2 x 2 factorial design to primary stenting or to balloon angioplasty, each with and without abciximab. Early thrombosis occurred in 19 patients (0.9%) at a median of 2 days (range 0 to 23). Maximal balloon diameter was smaller, and aneurysmal and bifurcation lesions were more prevalent in the group with early thrombosis. Early thrombosis occurred in 0.4% of patients who had been randomized to receive abciximab versus 1.5% of control patients (p
Volume
94
Issue
8
First Page
983
Last Page
988
ISSN
0002-9149
Published In/Presented At
Dangas, G., Aymong, E. D., Mehran, R., Tcheng, J. E., Grines, C. L., Cox, D. A., Garcia, E., Griffin, J. J., Guagliumi, G., Stuckey, T., Lansky, A. J., Stone, G. W., & CADILLAC Investigators (2004). Predictors of and outcomes of early thrombosis following balloon angioplasty versus primary stenting in acute myocardial infarction and usefulness of abciximab (the CADILLAC trial). The American journal of cardiology, 94(8), 983–988. https://doi.org/10.1016/j.amjcard.2004.06.050
Disciplines
Medicine and Health Sciences
PubMedID
15476608
Department(s)
Department of Medicine
Document Type
Article