Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection.
Publication/Presentation Date
11-1-1987
Abstract
Chronic cutaneous herpes simplex virus infection is described in a 68-year-old man who was immunocompromised because of chronic lymphocytic leukemia. The herpes infection was not amenable to therapy with acyclovir. Clinical isolates of herpes simplex virus were assessed for viral thymidine kinase activity, which was markedly decreased in two isolates. By the method of viral plaque autoradiography, these isolates were determined to be composed primarily of mutant thymidine kinase-negative herpes simplex virus mixed with occasional standard thymidine kinase-positive herpes simplex virus. Viral plaque autoradiography permitted the quantitation of proportions of thymidine kinase-negative and thymidine kinase-positive herpes simplex virus in the mixed virus populations. The chronic cutaneous infection persisted, unlike other reported infections by thymidine kinase-negative herpes simplex virus.
Volume
17
Issue
5 Pt 2
First Page
875
Last Page
880
ISSN
0190-9622
Published In/Presented At
Westheim, A. I., Tenser, R. B., & Marks, J. G., Jr (1987). Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection. Journal of the American Academy of Dermatology, 17(5 Pt 2), 875–880. https://doi.org/10.1016/s0190-9622(87)70272-2
Disciplines
Medicine and Health Sciences
PubMedID
2824577
Department(s)
Department of Medicine
Document Type
Article