Work-Related Asthma.
Publication/Presentation Date
10-1-2015
Abstract
OBJECTIVE: Summarize developed evidence-based diagnostic and treatment guidelines for work-related asthma (WRA).
METHODS: Comprehensive literature reviews conducted with article critiquing and grading. Guidelines developed by a multidisciplinary expert panel and peer-reviewed.
RESULTS: Evidence supports spirometric testing as an essential early test. Serial peak expiratory flow rates measurement is moderately recommended for employees diagnosed with asthma to establish work-relatedness. Bronchial provocation testing is moderately recommended. IgE and skin prick testing for specific high-molecular weight (HMW) antigens are highly recommended. IgG testing for HMW antigens, IgE testing for low-molecular weight antigens, and nitric oxide testing for diagnosis are not recommended. Removal from exposure is associated with the highest probability of improvement, but may not lead to complete recovery.
CONCLUSION: Quality evidence supports these clinical practice recommendations. The guidelines may be useful to providers who diagnose and/or treat WRA.
Volume
57
Issue
10
First Page
121
Last Page
129
ISSN
1536-5948
Published In/Presented At
Jolly, A. T., Klees, J. E., Pacheco, K. A., Guidotti, T. L., Kipen, H. M., Biggs, J. J., Hyman, M. H., Bohnker, B. K., Thiese, M. S., Hegmann, K. T., & Harber, P. (2015). Work-Related Asthma. Journal of occupational and environmental medicine, 57(10), e121–e129. https://doi.org/10.1097/JOM.0000000000000572
Disciplines
Medicine and Health Sciences
PubMedID
26461873
Department(s)
Department of Medicine
Document Type
Article