Temporal lobectomy: resection volume, neuropsychological effects, and seizure outcome.
Publication/Presentation Date
10-1-2009
Abstract
OBJECTIVE: The goal of the work described here was to evaluate relationships among resection volume, seizure outcome, and cognitive morbidity after temporal lobectomy for intractable epilepsy.
METHODS: Thirty patients with mesial temporal sclerosis were evaluated pre- and postoperatively with the Wechsler Adult Intelligence Scale III, Wechsler Memory Scale III, and three-dimensional coronal spoiled gradient recall acquisition MRI. Preoperative whole-brain volumes were calculated with Statistical Parametric Mapping. Resection volume was calculated by manual tracing. Systat was used for statistical analysis.
RESULTS: All resections included the temporal tip, at least 1cm of the superior temporal gyrus, and 3 to 5cm of the middle and inferior temporal gyri. Left were significantly smaller than right temporal resections. Seizure-free patients had significantly larger resections. Immediate verbal memory was significantly worse after left temporal lobectomy. Surgical outcome and resection volume did not affect postoperative neuropsychological results.
CONCLUSIONS: Dominant temporal lobe resections are associated with immediate verbal memory deficits. Larger resection volume was associated with improved seizure control but not worse cognitive outcome.
Volume
16
Issue
2
First Page
311
Last Page
314
ISSN
1525-5069
Published In/Presented At
Shamim, S., Wiggs, E., Heiss, J., Sato, S., Liew, C., Solomon, J., & Theodore, W. H. (2009). Temporal lobectomy: resection volume, neuropsychological effects, and seizure outcome. Epilepsy & behavior : E&B, 16(2), 311–314. https://doi.org/10.1016/j.yebeh.2009.07.040
Disciplines
Medicine and Health Sciences
PubMedID
19703792
Department(s)
Department of Medicine
Document Type
Article