Hyperglycemia after SAH: predictors, associated complications, and impact on outcome.
Publication/Presentation Date
1-1-2006
Abstract
BACKGROUND AND PURPOSE: Hyperglycemia is common after subarachnoid hemorrhage (SAH). The extent to which prolonged hyperglycemia contributes to in-hospital complications and poor outcome after SAH is unknown.
METHODS: We studied an inception cohort of 281 SAH patients with an initial serum glucose level obtained within 3 days of SAH onset and who had at least 7 daily glucose measurements between SAH days 0 and 10. We defined mean glucose burden (GB) as the average peak daily glucose level >5.8 mmol/L (105 mg/dL). Hospital complications were recorded prospectively, and 3-month outcome was assessed with the modified Rankin scale.
RESULTS: The median GB was 1.8 mmol/L (33 mg/dL). Predictors of high-GB included age > or =54 years, Hunt and Hess grade III-V, poor Acute Physiology and Chronic Health Evaluation (APACHE)-2 physiological subscores, and a history of diabetes mellitus (all P< or =0.001). In a multivariate analysis, GB was associated with increased intensive care unit length of stay (P=0.003) and the following complications: congestive heart failure, respiratory failure, pneumonia, and brain stem compression from herniation (all P
CONCLUSIONS: Hyperglycemia after SAH is associated with serious hospital complications, increased intensive care unit length of stay, and an increased risk of death or severe disability.
Volume
37
Issue
1
First Page
199
Last Page
203
ISSN
1524-4628
Published In/Presented At
Frontera, J. A., Fernandez, A., Claassen, J., Schmidt, M., Schumacher, H. C., Wartenberg, K., Temes, R., Parra, A., Ostapkovich, N. D., & Mayer, S. A. (2006). Hyperglycemia after SAH: predictors, associated complications, and impact on outcome. Stroke, 37(1), 199–203. https://doi.org/10.1161/01.STR.0000194960.73883.0f
Disciplines
Medicine and Health Sciences
PubMedID
16339481
Department(s)
Department of Medicine
Document Type
Article