Advances in revascularization for acute ischemic stroke treatment.
Publication/Presentation Date
3-1-2005
Abstract
Intravenous thrombolysis with recombinant tissue plasminogen activator is the established treatment for acute ischemic stroke patients presenting within 3 h after stroke onset. In a significant number of patients, however, intravenous thrombolysis with recombinant tissue plasminogen activator remains ineffective. New thrombolytic agents, such as reteplase, tenecteplase or desmoteplase, offer pharmacokinetic and dynamic advantages over recombinant tissue plasminogen activator and have been or are currently being tested for safety and efficacy in clinical trials. Endovascular revascularization is an evolving treatment option enabling mechanical clot disruption or extraction in combination with thrombolysis. Several new endovascular devices have been successfully tested for safety in acute ischemic stroke patients and are now being tested for efficacy in larger clinical trials. Continued innovation and refinement of endovascular technology and techniques is expected to increase technical success with a minimal procedure-related morbidity in the treatment of acute ischemic stroke.
Volume
5
Issue
2
First Page
189
Last Page
201
ISSN
1744-8360
Published In/Presented At
Schumacher, H. C., Gupta, R., Higashida, R. T., & Meyers, P. M. (2005). Advances in revascularization for acute ischemic stroke treatment. Expert review of neurotherapeutics, 5(2), 189–201. https://doi.org/10.1586/14737175.5.2.189
Disciplines
Medicine and Health Sciences
PubMedID
15853489
Department(s)
Department of Medicine
Document Type
Article