A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.
Publication/Presentation Date
5-1-2011
Abstract
Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nuc1 rats migrate faster than wild type astrocytes. Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. We demonstrate that AQP4 expression is elevated in the astrocytes in PFV conditions, and we hypothesize that this causes the cells to migrate abnormally into the vitreous where they ensheath the hyaloid artery. This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system.
Volume
90
Issue
5
First Page
440
Last Page
448
ISSN
1618-1298
Published In/Presented At
Zhang, C., Asnaghi, L., Gongora, C., Patek, B., Hose, S., Ma, B., Fard, M. A., Brako, L., Singh, K., Goldberg, M. F., Handa, J. T., Lo, W. K., Eberhart, C. G., Zigler, J. S., Jr, & Sinha, D. (2011). A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye. European journal of cell biology, 90(5), 440–448. https://doi.org/10.1016/j.ejcb.2011.01.003
Disciplines
Medicine and Health Sciences
PubMedID
21354650
Department(s)
Department of Medicine
Document Type
Article