Graft-versus-host disease in limb transplantation: digital image analysis of bone marrow and TGF-beta expression in situ using a novel 3-D microscope.
Publication/Presentation Date
8-1-1996
Abstract
A subpopulation of parental to hybrid VBMT recipients developed characteristic clinical and histopathologic manifestations of GVHD. These changes are similar to those seen in human GVHD secondary to bone marrow transplantation. Human GVHD also manifests itself in an acute and chronic manner. Only a minority (30% to 40%) of animals developed lethal GVHD in our model. Those animals developing GVHD had a significantly (P < .0001) higher expression of TGF-beta in situ compared to the tolerant subpopulation. The differential expression of TGF-beta may represent an important mechanism of immune dysregulation associated with GVHD in CTA recipients.
Volume
28
Issue
4
First Page
2029
Last Page
2031
ISSN
0041-1345
Published In/Presented At
Ramsamooj, R., Llull, R., Tatem, L. D., Black, K. S., Lotano, V., Dalsey, R. M., Born, C. T., DeLong, W. G., & Hewitt, C. W. (1996). Graft-versus-host disease in limb transplantation: digital image analysis of bone marrow and TGF-beta expression in situ using a novel 3-D microscope. Transplantation proceedings, 28(4), 2029–2031.
Disciplines
Medicine and Health Sciences
PubMedID
8769145
Department(s)
Department of Medicine
Document Type
Article