Leptin: pathogenesis and treatment of morbid obesity.
Publication/Presentation Date
8-1-2000
Abstract
Leptin is a hormone produced primarily by the adipocytes. It works through different receptors and seems to provide information to the hypothalamus about the energy status of the body. Although leptin appears to exert its anti-obesity effect through its central action, the full spectrum of its action is yet to be determined. Most obese subjects in studies have high serum levels of leptin, suggesting that the major problem is leptin resistance rather than leptin deficiency. Consequently, these patients may not respond to exogenous leptin. Recent trials have indicated, however, that leptin may have therapeutic potential in leptin-deficient as well as leptin-resistant states.
Volume
2
Issue
4
First Page
337
Last Page
344
ISSN
1522-8037
Published In/Presented At
Kumar, A., Inverso, N. A., & Still, C. D. (2000). Leptin: pathogenesis and treatment of morbid obesity. Current gastroenterology reports, 2(4), 337–344. https://doi.org/10.1007/s11894-000-0029-5
Disciplines
Medicine and Health Sciences
PubMedID
10981034
Department(s)
Department of Medicine
Document Type
Article