Antithrombotic effect of FK506 vs cyclosporine in cardiac transplant recipients: potential implications in transplant arteriopathy.
Publication/Presentation Date
12-1-1999
Abstract
BACKGROUND: An activated coagulation system has been implicated as a potential initiating or inciting factor in the development and progression of cardiac allograft vasculopathy (CAV).
METHODS: By performing ex vivo perfusion studies of blood thrombogenicity under constant rheologic conditions and with a constant substrate, we sought to determine the relative effects on the coagulation system of FK506 vs cyclosporine in patients who have undergone cardiac transplantation.
RESULTS-CONCLUSIONS: Compared with cyclosporine, FK506 significantly decreased the propensity to form thrombus; this suggests that FK506 may have a favorable impact on the development of CAV.
Volume
18
Issue
12
First Page
1228
Last Page
1231
ISSN
1053-2498
Published In/Presented At
Freudenberger, R., Alexis, J., Gass, A., Fuster, V., & Badimon, J. (1999). Antithrombotic effect of FK506 vs cyclosporine in cardiac transplant recipients: potential implications in transplant arteriopathy. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 18(12), 1228–1231. https://doi.org/10.1016/s1053-2498(99)00094-7
Disciplines
Medicine and Health Sciences
PubMedID
10612383
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article