Secretion of plasminogen activator by cerebral astrocytes and its modulation.
Publication/Presentation Date
9-1-1987
Abstract
Plasminogen activator (PA) has been related to the neuron migration during brain development. PA has also been shown to degrade myelin basic protein. We present data to show that neonatal Balb/c astrocytes show PA activity on 125I-fibrin coated plates. Secreted and cell associated fibrinolytic activity is detected only in the presence of plasminogen. Modulants like concanavalin A and phorbol myristate acetate enhance PA production and this function involves a transcriptional event. Dexamethasone inhibits baseline as well as concanavalin A induced enhancement of PA activity. These results raise the possibility that astrocytes may have an active role in myelinoclastic disorders and CNS developmental defects.
Volume
80
Issue
2-3
First Page
307
Last Page
321
ISSN
0022-510X
Published In/Presented At
Toshniwal, P. K., Tiku, M. L., Tiku, K., & Skosey, J. L. (1987). Secretion of plasminogen activator by cerebral astrocytes and its modulation. Journal of the neurological sciences, 80(2-3), 307–321. https://doi.org/10.1016/0022-510x(87)90165-1
Disciplines
Medicine and Health Sciences
PubMedID
3681335
Department(s)
Department of Medicine
Document Type
Article