The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage.
Publication/Presentation Date
5-1-1985
Abstract
Acute subarachnoid hemorrhage (SAH) and intraparenchymal hematoma (IPH) in cats are accompanied by massive cellular depolarization. This depolarization, characterized by potassium (K+) efflux and calcium (Ca++) influx, results in membrane destabilization, osmotic imbalance, and a decrease in electrical conduction. The Ca++ influx appears to initiate a chain reaction that, in some instances, may result in delayed cell destruction. The ionic dysequilibrium probably contributes to both brain engorgement and spasm in large vessels. The cellular depolarization and calcium-induced cell membrane injury at the moment of impact may play a greater role in the pathophysiology of head trauma than previously thought.
Volume
62
Issue
5
First Page
698
Last Page
703
ISSN
0022-3085
Published In/Presented At
Hubschmann, O. R., & Nathanson, D. C. (1985). The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage. Journal of neurosurgery, 62(5), 698–703. https://doi.org/10.3171/jns.1985.62.5.0698
Disciplines
Medicine and Health Sciences
PubMedID
3989592
Department(s)
Department of Medicine
Document Type
Article