Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence.
Publication/Presentation Date
12-1-2007
Abstract
To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5' region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P
Volume
7
Issue
6
First Page
368
Last Page
379
ISSN
1470-269X
Published In/Presented At
Xu, K., Anderson, T. R., Neyer, K. M., Lamparella, N., Jenkins, G., Zhou, Z., Yuan, Q., Virkkunen, M., & Lipsky, R. H. (2007). Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. The pharmacogenomics journal, 7(6), 368–379. https://doi.org/10.1038/sj.tpj.6500430
Disciplines
Medicine and Health Sciences
PubMedID
17200667
Department(s)
Department of Medicine
Document Type
Article