Clinical and histologic heterogeneity of psoriatic plaques. Therapeutic relevance.
Publication/Presentation Date
2-1-1988
Abstract
Twenty-three patients with resistant psoriasis vulgaris were evaluated clinically and histologically before and after treatment with potent topically administered steroids. It was shown that psoriatic plaques are comprised of clinically and histologically distinct acute and chronic areas, each responding differently to treatment. Chronic areas, characterized by chronic inflammation, respond well to therapy; acute areas, characterized by acute inflammation, are resistant to therapy. It is suggested that the psoriagenic stimulus is greater within the therapy-resistant "hot spots." Future therapy aimed at hot spots may aid in the better control of psoriasis.
Volume
124
Issue
2
First Page
216
Last Page
220
ISSN
0003-987X
Published In/Presented At
Griffin, T. D., Lattanand, A., & VanScott, E. J. (1988). Clinical and histologic heterogeneity of psoriatic plaques. Therapeutic relevance. Archives of dermatology, 124(2), 216–220.
Disciplines
Medicine and Health Sciences
PubMedID
3341801
Department(s)
Department of Medicine
Document Type
Article