CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling.
Publication/Presentation Date
1-22-1999
Abstract
Transcriptional coactivators may function as nuclear integrators by coordinating diverse signaling events. Here we show that the p65 (RelA) component of nuclear factor-kappaB (NF-kappaB) and p53 mutually repress each other's ability to activate transcription. Additionally, tumor necrosis factor-activated NF-kappaB is inhibited by UV light-induced p53. Both p65 and p53 depend upon the coactivator CREB-binding protein (CBP) for maximal activity. Increased levels of the coactivator relieve p53-mediated repression of NF-kappaB activity and p65-mediated repression of p53-dependent gene expression. Nuclear competition for limiting amounts of CBP provides a novel mechanism for altering the balance between the expression of NF-kappaB-dependent proliferation or survival genes and p53-dependent genes involved in cell cycle arrest and apoptosis.
Volume
274
Issue
4
First Page
1879
Last Page
1882
ISSN
0021-9258
Published In/Presented At
Wadgaonkar, R., Phelps, K. M., Haque, Z., Williams, A. J., Silverman, E. S., & Collins, T. (1999). CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. The Journal of biological chemistry, 274(4), 1879–1882. https://doi.org/10.1074/jbc.274.4.1879
Disciplines
Medicine and Health Sciences
PubMedID
9890939
Department(s)
Department of Medicine
Document Type
Article