Predictors of improvement in left ventricular ejection fraction with carvedilol for congestive heart failure.
Publication/Presentation Date
1-1-2000
Abstract
BACKGROUND: Beta-blocker therapy has been reported to improve survival and left ventricular ejection fraction (LVEF) in the setting of congestive heart failure (CHF). The magnitude and predictors of improved LVEF are unclear.
METHODS: A total of 295 patients were enrolled in the study. Inclusion criteria were LVEF
RESULTS: LVEF improved from 25% +/- 6% at baseline to 36%+/-12% at follow-up (Por =21 LVEF points in 30% of the NICM group versus 10% of the ischemic cardiomyopathy group. Conversely, the deltaLVEF was unchanged to minimally improved (< or =5 LVEF points) in 21% of the NICM group versus 52% of the ischemic cardiomyopathy group. Multivariable analysis identified NICM and recent onset of congestive heart failure as correlates of improved LVEF.
CONCLUSIONS: Carvedilol significantly improved LVEF, especially in patients with NICM and those with recent onset of CHF.
Volume
7
Issue
1
First Page
3
Last Page
7
ISSN
1071-3581
Published In/Presented At
O'Keefe, J. H., Jr, Magalski, A., Stevens, T. L., Bresnahan, D. R., Jr, Alaswad, K., Krueger, S. K., & Bateman, T. M. (2000). Predictors of improvement in left ventricular ejection fraction with carvedilol for congestive heart failure. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 7(1), 3–7. https://doi.org/10.1067/mnc.2000.102678
Disciplines
Medicine and Health Sciences
PubMedID
10698228
Department(s)
Department of Medicine
Document Type
Article