Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy.
Publication/Presentation Date
4-7-2020
Abstract
OBJECTIVE: To examine occurrence of severe adverse fetal outcomes (SAO), including fetal loss and major congenital malformations (MCMs), in pregnant women with epilepsy (PWWE) vs healthy pregnant women (HPW).
METHODS: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes for both mother and child, which enrolled women December 2012 through January 2016.
RESULTS: The 351 PWWE had 365 conceptions, and 105 HPW had 109 conceptions. SAOs occurred more often in PWWE (7.9%) vs HPW (1.9%) (
CONCLUSIONS: The findings provide additional information on risks of SAOs in PWWE, assessing effects of both AED levels and periconceptional folate. Group differences in average enrollment gestational age could have affected fetal loss results. Analyses are limited by small sample sizes as the MONEAD study was not powered for these secondary outcomes. The large majority of pregnancies in women with epilepsy do not have SOAs.
Volume
94
Issue
14
First Page
1502
Last Page
1502
ISSN
1526-632X
Published In/Presented At
Meador, K. J., Pennell, P. B., May, R. C., Van Marter, L., McElrath, T. F., Brown, C., Gerard, E., Kalayjian, L., Gedzelman, E., Penovich, P., Cavitt, J., French, J., Hwang, S., Pack, A. M., Sam, M., Birnbaum, A. K., Finnell, R., & MONEAD Investigator Group (2020). Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy. Neurology, 94(14), e1502–e1511. https://doi.org/10.1212/WNL.0000000000008687
Disciplines
Medicine and Health Sciences
PubMedID
31806691
Department(s)
Department of Medicine
Document Type
Article