Pharmacokinetics of liposomal amphotericin B in pleural fluid.

Authors

Brad Moriyama
Parizad Torabi-Parizi
Alexandra K Pratt
Stacey A Henning
Gennethel Pennick
Yvonne R Shea
Sinchita Roy Chowdhuri
Michael G Rinaldi
A John Barrett
Thomas J Walsh

Publication/Presentation Date

4-1-2010

Abstract

We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC(pleural fluid)) to that in serum (AUC(serum)) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 microg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

Volume

54

Issue

4

First Page

1633

Last Page

1635

ISSN

1098-6596

Published In/Presented At

Moriyama, B., Torabi-Parizi, P., Pratt, A. K., Henning, S. A., Pennick, G., Shea, Y. R., Roy Chowdhuri, S., Rinaldi, M. G., Barrett, A. J., & Walsh, T. J. (2010). Pharmacokinetics of liposomal amphotericin B in pleural fluid. Antimicrobial agents and chemotherapy, 54(4), 1633–1635. https://doi.org/10.1128/AAC.01438-09

Disciplines

Medicine and Health Sciences

PubMedID

20086161

Department(s)

Department of Medicine

Document Type

Article