The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation.
Publication/Presentation Date
1-1-2021
Abstract
Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably, emerging literature describes the role of immunoregulatory semaphorins and their receptors, plexins and neuropilins, as modulators of innate immunity and diseases defined by acute injury to the kidneys, abdomen, heart and lungs. In this review we discuss the pathogenic functions of semaphorins in clinical conditions of acute inflammation, including sepsis and acute lung injury, with a focus on regulation of the innate immune response as well as potential future therapeutic targeting.
Volume
12
First Page
672441
Last Page
672441
ISSN
1664-3224
Published In/Presented At
Kanth, S. M., Gairhe, S., & Torabi-Parizi, P. (2021). The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation. Frontiers in immunology, 12, 672441. https://doi.org/10.3389/fimmu.2021.672441
Disciplines
Medicine and Health Sciences
PubMedID
34012455
Department(s)
Department of Medicine
Document Type
Article