Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens.
Publication/Presentation Date
1-20-2015
Abstract
Upon infection, adaptive immune responses play catch-up with rapidly replicating pathogens. While mechanisms for efficient humoral responses to lymph-borne antigens have been characterized, the current paradigm for T cell responses to infections and particulate vaccines involves delayed migration of peripheral antigen-bearing dendritic cells (DCs) to lymph nodes (LNs), where they elicit effector T cell responses. Utilizing whole LN 3D imaging, histo-cytometry, and intravital 2-photon microscopy, we have identified a specialized population of DCs, enriched in the LN-resident CD11b(+) subset, which resides within the lymphatic sinus endothelium and scans lymph with motile dendrites. These DCs capture draining particles and present associated antigens to T lymphocytes, inducing T cell responses much sooner than and independently of migratory DCs. Thus, strategic DC subset positioning in LNs limits a potentially costly delay in generation of T cell responses to lymph-borne antigens, contributing to effective host defense. These findings are also highly relevant to vaccine design.
Volume
42
Issue
1
First Page
172
Last Page
185
ISSN
1097-4180
Published In/Presented At
Gerner, M. Y., Torabi-Parizi, P., & Germain, R. N. (2015). Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens. Immunity, 42(1), 172–185. https://doi.org/10.1016/j.immuni.2014.12.024
Disciplines
Medicine and Health Sciences
PubMedID
25607462
Department(s)
Department of Medicine
Document Type
Article