The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4
Publication/Presentation Date
5-21-2019
Abstract
Lymph nodes (LNs) play critical roles in adaptive immunity by concentrating in one location the antigens, antigen-presenting cells, and antigen-responsive lymphocytes involved in such responses. Recent studies have revealed nonrandom localization of innate and adaptive immune cells within these organs, suggesting that microanatomical positioning optimizes responses involving sparse cooperating cells. Here, we report that the peripheral localization of LN cDC2 dendritic cells specialized for MHC-II antigen presentation is matched by a similarly biased paracortical distribution of CD4
Volume
50
Issue
5
First Page
1188
Last Page
1201
ISSN
1097-4180
Published In/Presented At
Baptista, A. P., Gola, A., Huang, Y., Milanez-Almeida, P., Torabi-Parizi, P., Urban, J. F., Jr, Shapiro, V. S., Gerner, M. Y., & Germain, R. N. (2019). The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity, 50(5), 1188–1201.e6. https://doi.org/10.1016/j.immuni.2019.04.001
Disciplines
Medicine and Health Sciences
PubMedID
31053504
Department(s)
Department of Medicine
Document Type
Article