Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry.
Publication/Presentation Date
2-1-2024
Abstract
OBJECTIVES: To date, studies have not provided definitive answers regarding whether previous immune checkpoint inhibitor (ICI) treatment alters outcomes for cancer patients with COVID-19.
METHODS: The OnCovid registry (NCT04393974) was searched from February 27, 2020, to January 31, 2022, for patients who received systemic anti-cancer therapy in the 4 weeks before laboratory-confirmed COVID-19 diagnosis. Propensity-score matching using country, vaccination status, primary tumor type, sex, age, comorbidity burden, tumor stage, and remission status investigated differences in predefined clinical outcomes comparing those who had or had not received ICIs.
RESULTS: Of 3523 patients screened, 137 ICI-only and 1378 non-ICI met inclusion criteria. Before matching, ICI patients were older, male, enrolled at centers in Italy, and had histories of smoking, thoracic cancers, advanced cancer stages, and active malignancies (P ≤0.02). After matching, there were 120 ICI and 322 non-ICI patients. ICI patients had no differences (odds ratio: 95% CI) in presenting COVID-19 symptoms (0.69: 0.37-1.28), receipt of COVID-specific therapy (0.88: 0.54-1.41), 14-day (0.95: 0.56-1.61), or 28-day (0.79: 0.48-1.29) mortalities. However, ICI patients required less COVID-19-related hospitalization (0.37: 0.21-0.67) and oxygen therapy (0.51: 0.31-0.83) and developed fewer complications (0.57: 0.36-0.92).
CONCLUSION: In this propensity-score matched analysis, previous ICI therapy did not worsen and potentially improved COVID-19 outcomes in patients with cancer.
Volume
139
First Page
13
Last Page
20
ISSN
1878-3511
Published In/Presented At
Mostaghim, A., Minkove, S., Aguilar-Company, J., Ruiz-Camps, I., Eremiev-Eremiev, S., Dettorre, G. M., Fox, L., Tondini, C., Brunet, J., Carmona-García, M., Lambertini, M., Bower, M., Newsom-Davis, T., Sharkey, R., Pria, A. D., Rossi, M., Plaja, A., Salazar, R., Sureda, A., Prat, A., … OnCovid study group (2024). Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 139, 13–20. https://doi.org/10.1016/j.ijid.2023.11.021
Disciplines
Medicine and Health Sciences
PubMedID
38029831
Department(s)
Department of Medicine
Document Type
Article