In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and enterococci.
Publication/Presentation Date
3-1-1995
Abstract
The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resistant Enterococcus faecium, but showed poor activity against E. faecalis. In time-kill studies the drug was rapidly bactericidal against S. pneumoniae but failed to kill most enterococci, even in the presence of gentamicin or human serum.
Volume
21
Issue
3
First Page
169
Last Page
173
ISSN
0732-8893
Published In/Presented At
Johnson, C. C., Slavoski, L., Schwartz, M., May, P., Pitsakis, P. G., Shur, A. L., & Levison, M. E. (1995). In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and enterococci. Diagnostic microbiology and infectious disease, 21(3), 169–173. https://doi.org/10.1016/0732-8893(95)00068-l
Disciplines
Medicine and Health Sciences
PubMedID
7648837
Department(s)
Department of Medicine
Document Type
Article