An International Perspective on Preceding Infections in Guillain-Barré Syndrome: The IGOS-1000 Cohort.
Publication/Presentation Date
9-20-2022
Abstract
BACKGROUND AND OBJECTIVES: Infections play a key role in the development of Guillain-Barré syndrome (GBS) and have been associated with specific clinical features and disease severity. The clinical variation of GBS across geographical regions has been suggested to be related to differences in the distribution of preceding infections, but this has not been studied on a large scale.
METHODS: We analyzed the first 1,000 patients included in the International GBS Outcome Study with available biosamples (n = 768) for the presence of a recent infection with
RESULTS: Serologic evidence of a recent infection with
DISCUSSION: Across geographical regions, the distribution of infections was similar, but the association between infection and clinical phenotype differed. A mismatch between symptom reporting and serologic results and the high frequency of coinfections demonstrate the importance of broad serologic testing in identifying the most likely infectious trigger. The association between infections and outcome indicates their value for future prognostic models.
Volume
99
Issue
12
First Page
1299
Last Page
1299
ISSN
1526-632X
Published In/Presented At
Leonhard, S. E., van der Eijk, A. A., Andersen, H., Antonini, G., Arends, S., Attarian, S., Barroso, F. A., Bateman, K. J., Batstra, M. R., Benedetti, L., van den Berg, B., Van den Bergh, P., Bürmann, J., Busby, M., Casasnovas, C., Cornblath, D. R., Davidson, A., Doets, A. Y., van Doorn, P. A., Dornonville de la Cour, C., … IGOS Consortium (2022). An International Perspective on Preceding Infections in Guillain-Barré Syndrome: The IGOS-1000 Cohort. Neurology, 99(12), e1299–e1313. https://doi.org/10.1212/WNL.0000000000200885
Disciplines
Medicine and Health Sciences
PubMedID
35981895
Department(s)
Department of Medicine
Document Type
Article