Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life.

Authors

Christopher C Copenhaver
James E Gern
Zhanhai Li
Peter A Shult
Louis A Rosenthal
Lance D Mikus
Carol J Kirk
Kathy A Roberg
Elizabeth L Anderson
Christopher J Tisler
Douglas F DaSilva
Heidi J Hiemke
Kevin Gentile
Ronald E Gangnon
Robert F Lemanske

Publication/Presentation Date

7-15-2004

Abstract

Daycare attendance and siblings are associated with viral-induced wheezing in children. Preexisting immunologic factors may influence the expression of viral infections in infancy, and in turn, recurrent infections may influence the development of immune responses. A total of 285 children were enrolled in the Childhood Origins of Asthma Project at birth and followed for at least 1 year. Cord blood and 1-year mononuclear cells were stimulated with phytohemagglutinin, and cytokine-response profiles were measured by enzyme-linked immunosorbent assay. Nasal lavage was performed for moderate to severe respiratory illnesses. Daycare attendance and/or siblings significantly increased the likelihood of contracting respiratory syncytial virus (1.5-1.6-fold increase) and rhinovirus (1.8-2.1-fold increase), and increased the risk of rhinovirus-induced wheezing (14-18% vs. 2%, p = 0.011). Cord blood IFN-gamma responses were inversely related to the frequency of viral respiratory infections (r(s) = -0.11, p = 0.05), and more significant for subjects with high exposure to other children (r(s) = -0.27, p = 0.028). The interval change in infantile IFN-gamma responses correlated positively with the frequency of viral infections in infancy (r(s) = 0.12, p = 0.047). These data suggest that neonatal IFN-gamma responses may influence antiviral activity, or may represent a marker of antiviral immunity maturation. Conversely, the frequency of viral infections in infancy can influence IFN-gamma responses.

Volume

170

Issue

2

First Page

175

Last Page

180

ISSN

1073-449X

Published In/Presented At

Copenhaver, C. C., Gern, J. E., Li, Z., Shult, P. A., Rosenthal, L. A., Mikus, L. D., Kirk, C. J., Roberg, K. A., Anderson, E. L., Tisler, C. J., DaSilva, D. F., Hiemke, H. J., Gentile, K., Gangnon, R. E., & Lemanske, R. F., Jr (2004). Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life. American journal of respiratory and critical care medicine, 170(2), 175–180. https://doi.org/10.1164/rccm.200312-1647OC

Disciplines

Medicine and Health Sciences

PubMedID

15087299

Department(s)

Department of Medicine

Document Type

Article