Renal effects of guanabenz: a new antihypertensive.
Publication/Presentation Date
1-1-1976
Abstract
In order to determine the effects of guanabenz upon renal function, clearance studies were performed on hypertensive volunteers during sustained steady-state water diuresis. The data reveal an acute fall in renal hemodynamics and a marked reduction in sodium excretion during the 3rd and 4th hour after administration. Tha antinatriuresis was due to decreased filtration and enhanced distal nephron reabsorption of sodium, principally in association with secretion of potassium. Chronic administration of guanabenz for one week produced a sustained reduction in blood pressure, but there was no change in either body weight or 24-hour urinary sodium excretion. Repeat clearance studies revealed no change with either renal hemodynamics or sodium clearance. The data suggest that the acute antinatriuresis is a transient hemodynamic event and chronic therapy with guanabenz will not be complicated by sodium retention, a feature characteristic of other antihypertensive agents.
Volume
16
Issue
11-12
First Page
631
Last Page
636
ISSN
0091-2700
Published In/Presented At
Bosanac, P., Dubb, J., Walker, B., Goldberg, M., & Agus, Z. S. (1976). Renal effects of guanabenz: a new antihypertensive. Journal of clinical pharmacology, 16(11-12), 631–636. https://doi.org/10.1002/j.1552-4604.1976.tb01502.x
Disciplines
Medicine and Health Sciences
PubMedID
993358
Department(s)
Department of Medicine
Document Type
Article