Secondary hormonal manipulation of prostate cancer.
Publication/Presentation Date
8-1-2002
Abstract
Prostate cancer is the second leading cause of cancer mortality among men in Western countries. The initial treatment of advanced prostate cancer is suppression of testicular androgen production by medical or surgical castration, but nearly all men with metastases will develop disease progression. Patients with hormone-resistant prostate cancer (HRPC) have a median survival of approximately 18 months, and no therapy has yet demonstrated a definitive survival advantage. However, in the past several years, a number of promising new treatment strategies have emerged. One of the most important new treatment strategies involves secondary hormonal manipulation after the failure of primary androgen deprivation. This approach is predicated on the recognition that HRPC is a heterogeneous disease, and some patients may respond to alternative hormonal interventions despite the presence of castrate levels of testosterone.
Volume
20
Issue
3 Suppl 1
First Page
24
Last Page
30
ISSN
1081-0943
Published In/Presented At
Small, E. J., & Harris, K. A. (2002). Secondary hormonal manipulation of prostate cancer. Seminars in urologic oncology, 20(3 Suppl 1), 24–30. https://doi.org/10.1053/suro.2002.35054
Disciplines
Medicine and Health Sciences
PubMedID
12198635
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article