Bilateral Adult Wilms' Tumor.

Publication/Presentation Date

3-15-1987

Abstract

Bilateral Wilms' tumors in children are not uncommon but in the adult are quite rare. A two-mutation theory of oncogenesis has been proposed in which a prezygotic gene mutation and a postzygotic mutation lead to the development of Wilms' tumor. However, the recent discovery of a postzygotic deletion within the 11p13 band of chromosome 11 in adult cases of Wilms' tumor may explain the rarity of the bilateral form in later years. Early diagnosis is difficult because of the nonspecificity of signs and symptoms. Computer tomography, ultrasonography, and arteriography are important modalities in the earlier diagnosis of adult Wilms' tumor. Because of the rarity of these tumors, no definitive guidelines for treatment have emerged. However, a multidisciplinary approach incorporating surgery, chemotherapy and/or radiation therapy has been used most often but with varying success. This report documents the second case of bilateral adult Wilms' tumor presenting as perinephric hematomas which partially resolved.

Volume

59

Issue

6

First Page

1210

Last Page

1213

ISSN

0008-543X

Disciplines

Medical Sciences | Medicine and Health Sciences

PubMedID

3028598

Department(s)

Department of Medicine, Department of Medicine Faculty

Document Type

Article

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