Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device.
Publication/Presentation Date
2-1-1992
Abstract
A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recruited as part of a phase 1 study. Thirteen eyes with active CMV retinitis underwent surgical implantation of the ganciclovir device. All eyes showed resolution of the CMV retinitis; none showed progression. Visual acuity remained unchanged in three eyes, improved in six eyes, and decreased in four eyes. Surgical complications included mild vitreous hemorrhage, astigmatism, and suprachoroidal placement of the device. Retinal detachment occurred in three eyes as the retinitis resolved. This new intraocular drug delivery system offers many advantages compared with intravenous therapy or repeated intravitreal ganciclovir injections for the management of CMV retinitis in patients with AIDS.
Volume
110
Issue
2
First Page
188
Last Page
195
ISSN
0003-9950
Published In/Presented At
Sanborn, G. E., Anand, R., Torti, R. E., Nightingale, S. D., Cal, S. X., Yates, B., Ashton, P., & Smith, T. (1992). Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device. Archives of ophthalmology (Chicago, Ill. : 1960), 110(2), 188–195. https://doi.org/10.1001/archopht.1992.01080140044023
Disciplines
Medicine and Health Sciences
PubMedID
1310587
Department(s)
Department of Medicine
Document Type
Article