CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease.
Publication/Presentation Date
12-1-2008
Abstract
CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways that contribute to multiple pathophysiological processes. A role for CD40-CD40L interactions has been identified in atherosclerosis, and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors. The CD40-CD40L interaction has also been implicated in immune system disorders. Recent studies have suggested that CD40-CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and cardiovascular systems. Here, we discuss the emerging role of CD40-CD40L-mediated processes in oxidative stress, inflammatory pathways and vascular diseases. Understanding the roles and regulation of CD40-CD40L-mediated oxidative signaling in immune and non-immune cells could facilitate the development of therapeutics targeting diverse inflammatory diseases.
Volume
14
Issue
12
First Page
530
Last Page
538
ISSN
1471-4914
Published In/Presented At
Rizvi, M., Pathak, D., Freedman, J. E., & Chakrabarti, S. (2008). CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends in molecular medicine, 14(12), 530–538. https://doi.org/10.1016/j.molmed.2008.09.006
Disciplines
Medicine and Health Sciences
PubMedID
18977174
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article