Preliminary results, serum chemistry values before and after the intravaginal administration of 5% nonoxynol-9 cream.
Publication/Presentation Date
6-1-1981
Abstract
Thirty-two healthy premenopausal women between the ages of 18 and 39 were randomly assigned to three study groups as follows: Group I received daily intravaginal administration of 2.5 gm of 5% nonoxynol-9 vaginal cream (Conceptrol [Ortho Pharmaceutical Corporation, Raritan, N. J.] cream) for 14 days. Group II received daily intravaginal administration of 2.5 gm of the cream base alone, and group III received no treatment. The numbers of subjects completing the study were 12, 11, and 7 groups I, II and III, respectively. Fasting blood samples were obtained from each subject prior to treatment and on days 8 and 15 after treatment. Blood samples were analyzed for 20 constituents, including proteins, lipids, triglycerides, and serum enzymes. There were no differences in any of the measured parameters between the pre- and post-treatment periods in any of the groups. On the basis of these findings it may be concluded that there are no apparent systemic effects following daily intravaginal administration of a 125-mg dose of nonoxynol-9 in a cream base for 2 weeks.
Volume
35
Issue
6
First Page
647
Last Page
652
ISSN
0015-0282
Published In/Presented At
Malyk B. (1981). Preliminary results, serum chemistry values before and after the intravaginal administration of 5% nonoxynol-9 cream. Fertility and sterility, 35(6), 647–652. https://doi.org/10.1016/s0015-0282(16)45558-5
Disciplines
Medicine and Health Sciences
PubMedID
6113993
Department(s)
Department of Medicine
Document Type
Article