Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis.
Publication/Presentation Date
8-1-1979
Abstract
The bladder complications of 54 patients treated with oral cyclophosphamide for systemic lupus erythematosus (43) or rheumatoid arthritis (11) were reviewed. During an observation period of 241 patient years, we saw seven cases of acute hemorrhagic cystitis and two cases of transitional cell carcinoma of the bladder. Bladder carcinoma was identified 28 and 60 months after withdrawal of the drug and resulted in the death of one patient. The late-occurring serious toxicities of cyclophosphamide should limit the use of the drug in the treatment of nonmalignant inflammatory rheumatic conditions.
Volume
91
Issue
2
First Page
221
Last Page
223
ISSN
0003-4819
Published In/Presented At
Plotz, P. H., Klippel, J. H., Decker, J. L., Grauman, D., Wolff, B., Brown, B. C., & Rutt, G. (1979). Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis. Annals of internal medicine, 91(2), 221–223. https://doi.org/10.7326/0003-4819-91-2-221
Disciplines
Medicine and Health Sciences
PubMedID
464465
Department(s)
Department of Medicine
Document Type
Article