A Case of Pembrolizumab-Induced Myasthenia Gravis.
Publication/Presentation Date
9-1-2023
Abstract
With the advent of new cancer treatments, immunotherapy has emerged as an increasingly promising strategy. Undoubtedly, it has pushed oncology into a new era and is providing patients with unprecedented results. As with many treatments, however, adverse effects lead to setbacks in progress. Pembrolizumab is an immunomodulating medication that functions by binding to programmed cell death protein 1 (PD-1) receptors of T cells thereby upregulating the immune system to more effectively detect and target cancer. Myasthenia gravis (MG) is a reported side effect of this medication. Our patient is an 87-year-old male with urothelial cell bladder cancer who developed MG following the administration of pembrolizumab and was treated with plasma exchange therapy. We aim to examine the existing literature concerning treatments for MG, with a particular focus on myasthenia gravis induced by pembrolizumab. We will discuss the occurrence rates and results of such instances, along with their implications for the future of these potential therapies.
Volume
15
Issue
9
First Page
45455
Last Page
45455
ISSN
2168-8184
Published In/Presented At
Kosick, T. I., Patel, K., Jasinski, J., & Dada, B. (2023). A Case of Pembrolizumab-Induced Myasthenia Gravis. Cureus, 15(9), e45455. https://doi.org/10.7759/cureus.45455
Disciplines
Medicine and Health Sciences
PubMedID
37859893
Department(s)
Department of Medicine
Document Type
Article