Sialyltransferase, sialic acid and sialoglycoconjugates in metastatic tumor and human liver tissue.
Publication/Presentation Date
1-1-1982
Abstract
1. The specific activities of sialytransferase in metastatic tumor sites were 5-37% of those of uninvolved non-cancerous tissue. The non-cancerous host tissues had a slightly lower average sialyltransferase activity than that of non-pathological control livers (986 vs 1194 dpm/min/mg protein). 2. The levels of total and bound sialic acid are increased 1.4 to 7.2-fold in homogenates, supernatants and resuspended pellets of metastatic tumor sites compared to non-cancerous and non-pathological control livers. For all these tissues, 24-29% of the bound sialic acid is found on soluble components (in the 16,300 g supernatant). 3. Soluble sialoglycoconjugates from most metastatic tumor sites give gel filtration profiles different from those of non-cancerous and non-pathological control livers.
Volume
14
Issue
2
First Page
119
Last Page
126
ISSN
0020-711X
Published In/Presented At
Alhadeff, J. A., & Holzinger, R. T. (1982). Sialyltransferase, sialic acid and sialoglycoconjugates in metastatic tumor and human liver tissue. The International journal of biochemistry, 14(2), 119–126. https://doi.org/10.1016/0020-711x(82)90151-3
Disciplines
Medicine and Health Sciences
PubMedID
6175543
Department(s)
Department of Medicine
Document Type
Article