Presence of an atypical thermolabile species of beta-hexosaminidase B in metastatic-tumour tissue of human liver.
Publication/Presentation Date
1-1-1982
Abstract
An atypical thermolabile species of Hex B (hexosaminidase B) has been found in metastatic-tumour sites of human liver which has a thermostability curve similar to that of Hex A (hexosaminidase A), which is present in decreased amounts relative to the Hex A isoenzyme, and which exhibits decreased relative activity at acidic pH values (2.6-3.6) when compared with control-liver Hex B. This atypical Hex B isoenzyme has a normal apparent Michaelis constant (0.6 mM) for 4-methylumbelliferyl 2-deoxy-2-acetamido-beta-D-glucopyranoside. The presence of this atypical Hex B suggests that variant beta-chains are being produced in metastatic-tumour tissue.
Volume
201
Issue
1
First Page
95
Last Page
99
ISSN
0264-6021
Published In/Presented At
Alhadeff, J. A., & Holzinger, R. T. (1982). Presence of an atypical thermolabile species of beta-hexosaminidase B in metastatic-tumour tissue of human liver. The Biochemical journal, 201(1), 95–99. https://doi.org/10.1042/bj2010095
Disciplines
Medicine and Health Sciences
PubMedID
6211170
Department(s)
Department of Medicine
Document Type
Article