Lysosomal hydrolases in cystic fibrosis livers.
Publication/Presentation Date
11-1-1978
Abstract
The specific activity of several lysosomal hydrolases in normal and cystic fibrosis (CF) livers has been investigated. Neuraminidase activity with respect to two natural substrates (fetuin and bovine submaxillary mucin) is normal in CF livers. No significant differences were found between CF and normal livers in 4-methylumbelliferyl-alpha-D-mannosidase specific activities determined at three different pH values (4.3, 5.65 and 6.5) corresponding to lysosomal, golgi and cytosolic components of the enzyme, respectively. The specific activities of p-nitrophenyl-beta-D-mannosidase and 4-methylumbelliferyl-beta-N-acetylglucosaminidase were also both similar in CF and normal livers.
Volume
89
Issue
3
First Page
469
Last Page
473
ISSN
0009-8981
Published In/Presented At
Alhadeff J. A. (1978). Lysosomal hydrolases in cystic fibrosis livers. Clinica chimica acta; international journal of clinical chemistry, 89(3), 469–473. https://doi.org/10.1016/0009-8981(78)90411-4
Disciplines
Medicine and Health Sciences
PubMedID
709887
Department(s)
Department of Medicine
Document Type
Article